منابع مشابه
Targeting epigenetic readers in cancer.
From the Department of Haematology, Cambridge Institute for Medical Research (M.A.D., B.J.P.H.), Cambridge University Hospitals National Health Service Foundation Trust (M.A.D., B.J.P.H.), the Gurdon Institute and Department of Pathology (M.A.D., T.K.), and the Wellcome Trust and Medical Research Council Cambridge Stem Cell Institute (B.J.P.H.), University of Cambridge — all in Cambridge, Unite...
متن کاملTargeting epigenetic regulations in cancer.
Epigenetic regulation of gene expression is a dynamic and reversible process with DNA methylation, histone modifications, and chromatin remodeling. Recently, groundbreaking studies have demonstrated the importance of DNA and chromatin regulatory proteins from different aspects, including stem cell, development, and tumor genesis. Abnormal epigenetic regulation is frequently associated with dise...
متن کاملTargeting eNOS in pancreatic cancer.
Mortality from pancreatic ductal adenocarcinoma cancer (PDAC) is among the highest of any cancer and frontline therapy has changed little in years. Activation of endothelial nitric oxide synthase (eNOS, NOS3, or NOS III) has been implicated recently in the pathogenesis of PDACs. In this study, we used genetically engineered mouse and human xenograft models to evaluate the consequences of target...
متن کاملEpigenetics and epigenetic alterations in pancreatic cancer.
Pancreatic cancer remains a major therapeutic challenge. In 2008, there will be approximately 37,680 new cases and 34,290 deaths attributable to pancreatic cancer in the United States (U.S.), making it the fourth leading cause of cancer-related death. Recent comprehensive pancreatic cancer genome project found that pancreatic adenocarcinomas harbored 63 intragenic mutations or amplifications/ho...
متن کاملTargeting Epigenetic Regulation of miR-34a for Treatment of Pancreatic Cancer by Inhibition of Pancreatic Cancer Stem Cells
BACKGROUND MicroRNA-34a (miR-34a) is a transcriptional target of p53 and is down-regulated in pancreatic cancer. This study aimed to investigate the functional significance of miR-34a in pancreatic cancer progression through its epigenetic restoration with chromatin modulators, demethylating agent 5-Aza-2'-deoxycytidine (5-Aza-dC) and HDAC inhibitor Vorinostat (SAHA). METHODOLOGY/PRINCIPAL FI...
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ژورنال
عنوان ژورنال: Cancer Treatment Reviews
سال: 2014
ISSN: 0305-7372
DOI: 10.1016/j.ctrv.2013.12.002